Research/Registration of a live Pasteurella multocida vaccine
From Poultry Hub
Title: Registration of a live Pasteurella multocida vaccine
Project Leader: Peter Scott at University of Melbourne funded by Poultry CRC (Project 03-12)
Duration of Project: 1 July 2004 to 31 January 2010
Contents |
Project overview
Caused by the bacteria Pasteurella multocida, Fowl cholera (or pasteurellosis) is a disease that afflicts commercial poultry, including turkeys and ducks, resulting in significant production losses, particularly in alternative production systems such as barn and free range.
Increasing restrictions on the use of antibiotics and the limited efficaciousness of killed autogenous vaccines has limited the ability to control this disease in the increasing numbers of birds that are being maintained under barn or free range conditions. A live P. multocida candidate vaccine, PMP1 or Vaxsafe® PM, has been shown to be safe and efficacious in the control of Fowl Cholera.
Project objectives
- Complete work required for the registration of PMP1 in chickens;
- Develop procedures for testing the vaccine in turkeys and ducks;
- Complete work required for the registration of PMP1 in turkeys and ducks.
Project progress
The laboratory aspect of the work with Vaxsafe PM in chickens has been essentially completed and will conclude with several more duration of immunity studies in the third quarter of 2008. The first large field study in commercial layers has commenced and will look at the safety of the vaccine when used under normal industry conditions. Other chicken farms including cage, barn and free range facilities have been identified for long term field studies to look at the both the efficacy and safety of Vaxsafe PM. Laboratory studies in turkeys are to commence in the second half of 2008.
