Research/Phage-displayed peptides are antimicrobial towards Campylobacter jejuni in chickens
From Poultry Hub
Title: Phage-displayed peptides are antimicrobial towards Campylobacter jejuni in chickens
Project Leader: Sharon Bishop-Hurley at CSIRO funded by Poultry CRC (Project 06-09)
Duration of Project: 1 July 2006 to 1 December 2009
Contents |
Project overview
Campylobacter jejuni is a leading cause of zoonotic food-borne illnesses in humans, with chicken meat being a major source of this infection. Current strategies for reducing the persistence and colonisation of this microorganism in the gastrointestinal tract of chickens are proving ineffective. Therapeutics targeted at reducing C. jejuni from the gastrointestinal tract of chickens would limit the incidence of this food-borne illness in humans.
Project objectives
- Use peptide phage-display to target cell surface receptors on C. jejuni involved in colonisation and persistence in the gastrointestinal tract of chickens; and
- Test phage peptides for specific antimicrobial activity against C. jejuni in vitro.
Project progress
A subtractive phage display approach is currently being used to affinity select for peptides binding to the cell surface of C. jejuni.
