Research/Vectoring antigens to the chicken immune system - studies with Campylobacter antigens
From Poultry Hub
Title: Vectoring antigens to the chicken immune system - studies with Campylobacter antigens
Project Leader: Peter Smooker at RMIT University funded by Poultry CRC (Project 07-25)
Duration of Project: 1 July 2007 to 31 December 2009
Contents |
Project overview
The vaccination of chickens against disease is desirable to prevent both disease in the flock and also to reduce the burden of pathogens that may be passed on to the food chain, and cause human disease. In the case of Campylobacter spp., the latter is the desired result - to reduce colonisation of the chicken and so transmission of this chicken commensal into the food chain where it can be transmitted to people, where enteric disease can result. However, there is currently no immunological means to reduce colonisation of Campylobacter spp, and so control remains a serious industry concern.
Vaccination with antigens delivered by STM-1 may be one viable approach. STM1 is an attenuated Salmonella vaccine developed at RMIT University, and is licensed to Bioproperties as a Salmonella vaccine for use in chickens.
Project objectives
The aim of this project is to develop a vectoring system that can deliver heterologous antigen to chickens. This will be examined using antigens derived from Campylobacter spp, with the aim of reducing colonisation in chickens.
Project progress
Antigens have been selected and inserted into STM-1 for analysis in chickens.
