{"text_format":"1","workbook":"xlsx","n_sheets":5,"sheets":["HOME","Instructions","Levels & Reps","Simulations","Calculations"],"not_rendered":{"charts":2,"images":8,"macros":1,"external_links":0,"defined_names":195,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"HOME","index":0,"n_rows":13,"n_cols":16,"rows_kept":13,"cut":false,"hidden":false,"merged":[[2,8,2,12],[3,8,3,12]]}
[]
[null,"Maximum Ingredient Optimization Workbook"]
[null,null,null,null,null,null,null,null,"\"MIOW\""]
[null,null,null,null,null,null,null,null,"Verson 1.0"]
[]
[null,"A workbook to determine the maximum safe level of feed ingredients"]
[]
[]
[null,null,"Dmitry V. Vedenov",null,null,null,null,null,null,"Gene M. Pesti",null,null,null,null,null,"Rashed A. Alhotan"]
[null,null,"Department of Agricultural Economics",null,null,null,null,null,null,"Department of Poultry Science",null,null,null,null,null,"Department of Poultry Science"]
[null,null,"Texas A&M University",null,null,null,null,null,null,"The University of Georgia",null,null,null,null,null,"The University of Georgia"]
[null,null,"College Station, TX 77843",null,null,null,null,null,null,"Athens, Georgia 30602",null,null,null,null,null,"Athens, Georgia 30602"]
[null,null,"vedenov@tamu.edu",null,null,null,null,null,null,"gpesti@uga.edu",null,null,null,null,null,"ralhota1@uga.edu"]

{"sheet":"Instructions","index":1,"n_rows":12,"n_cols":2,"rows_kept":12,"cut":false,"hidden":false,"merged":[]}
[]
[null,"Instructions"]
[null,"1. Make changes in cells C5:C6 and C8:C9"]
[null,"2. Press \"Create Grid\" button"]
[null,"3. If you want to adjust levels, edit directly in corresponding cells"]
[null,"4. Select baseline model which will be used to generate random data"]
[null,"5. Enter \"true\" coefficients of the baseline mode"]
[null,"6. Provide guesses for coefficients for all remaining models (this is necessary to ensure convergence of Solver Routine)"]
[null,"6. Select simulation parameters (number of \"experiments\" and coefficient of variation for random draws)"]
[null,"7. Press \"Run Simulations\""]
[]
[null,"Note: If you end up with poor estimates for a particular model, try to provide more accurate initial guesses for the coefficients"]

{"sheet":"Levels & Reps","index":2,"n_rows":27,"n_cols":10,"rows_kept":27,"cut":false,"hidden":false,"merged":[[1,7,1,13],[9,5,9,9],[11,3,26,3]]}
[]
[null,null,null,null,null,null,null,"Experimental Grid"]
[null,"1. Experiment Design"]
[]
[null,"Number of Levels (>1, < 25)",5]
[null,"Number of Reps (max = 20)",16]
[]
[null,"Minimum Ingredient Level",0]
[null,"Maximum Ingredient Level",21]
[null,null,null,null,null,"Levels"]
[null,null,null,null,null,1,2,3,4,5]
[null,null,null,"Replicates",1,0,5.25,10.5,15.75,21]
[null,null,null,null,2,0,5.25,10.5,15.75,21]
[null,null,null,null,3,0,5.25,10.5,15.75,21]
[null," ",null,null,4,0,5.25,10.5,15.75,21]
[null,null,null,null,5,0,5.25,10.5,15.75,21]
[null,null,null,null,6,0,5.25,10.5,15.75,21]
[null,null,null,null,7,0,5.25,10.5,15.75,21]
[null,null,null,null,8,0,5.25,10.5,15.75,21]
[null,null,null,null,9,0,5.25,10.5,15.75,21]
[null,null,null,null,10,0,5.25,10.5,15.75,21]
[null,null,null,null,11,0,5.25,10.5,15.75,21]
[null,null,null,null,12,0,5.25,10.5,15.75,21]
[null,null,null,null,13,0,5.25,10.5,15.75,21]
[null,null,null,null,14,0,5.25,10.5,15.75,21]
[null,null,null,null,15,0,5.25,10.5,15.75,21]
[null,null,null,null,16,0,5.25,10.5,15.75,21]

{"sheet":"Simulations","index":3,"n_rows":140,"n_cols":20,"rows_kept":140,"cut":false,"hidden":false,"merged":[[34,15,34,19],[34,9,34,13],[34,3,34,7],[33,3,33,19],[2,2,2,6],[2,10,2,14],[18,3,18,6],[33,2,35,2],[4,3,4,6],[16,2,16,6],[4,10,4,13],[5,10,5,13],[6,10,6,13]]}
[]
[]
[null,null,"2. Choose One Model to Simulate Experiments From",null,null,null,null,null,null,null,"4. Choose Simulation Parameters"]
[]
[null,null,"Model","True Parameters of the Response Function",null,null,null,null,null,null,"Selected (\"True\") Model",null,null,null,"BLQ"]
[null,null,null,"Max","Rate Constant","Ingredient Level",null,null,null,null,"Number of Experiments (Max = 1000)",null,null,null,100]
[null,null,null,56.1,-18.828384062673344,6,null,null,null,null,"Coefficient of variation",null,null,null,0.05]
[null,null,null,"Max","Rate Constant","Ingredient Level"]
[null,null,null,0.64200000000000002,-1.74,16]
[null,null,null,"Const","Linear","Quadratic",null,null,null,null,null,null,null,null,null," "]
[null,null,null,2.1821000000000002,1.6000000000000001E-3,-3.0000000000000001E-5]
[]
[]
[]
[]
[]
[null,null,"3. Select up to Three Models to Fit to Simulated Experiments"]
[]
[null,null,"Model","Initial Guesses for the Parameters of Fitted Functions"]
[null,null,null,"Max","Rate Constant","Ingredient Level"]
[null,null,null,0.64200000000000002,-18.828384062673344,16]
[null,null,null,"Max","Rate Constant","Ingredient Level"]
[null,null,null,0.64200000000000002,-1.74,16]
[null,null,null,"Const","Linear","Quadratic"]
[null,null,null,2.0122,6.2399999999999997E-2,-2.3E-3]
[]
[]
[]
[]
[]
[]
[null,null,"5. Results"]
[]
[null,null,"Experiment #","Model Fits"]
[null,null,null,"Broken Line Model",null,null,null,null,null,"Broken Line Quadratic Model",null,null,null,null,null,"Quadratic (2nd Order Polynomial)"]
[null,null,null,"Max/Min","Rate Constant","Maximum Safe Level","R-Squared","SE of Requirement",null,"Max/Min","Rate Constant","Maximum Safe Level","R-Squared","SE of Requirement",null,"Const","Linear","Square","Max. Safe Level (Calculated)","R-Squared"]
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[null,null,"Std. Dev.",{"$f":"IF(OR(ISBLANK(D$41),ISNA(D$41),D$41=\"N/A\"),\"N/A\",STDEV(D$41:D$1040))","v":3.9982534961571165E-3},{"$f":"IF(OR(ISBLANK(E$41),ISNA(E$41),E$41=\"N/A\"),\"N/A\",STDEV(E$41:E$1040))","v":0.49516956992001876},6.858233234745624E-2,1.2273609494207996E-3,{"$error":"#NUM!"},null,{"$f":"IF(OR(ISBLANK(J$41),ISNA(J$41),J$41=\"N/A\"),\"N/A\",STDEV(J$41:J$1040))","v":4.050049950504891E-3},2.1493814564835179E-2,3.1737319451883128E-2,1.2273622124086339E-3,{"$error":"#NUM!"},null,{"$f":"IF(OR(ISBLANK(P$41),ISNA(P$41),P$41=\"N/A\"),\"N/A\",STDEV(P$41:P$1040))","v":"N/A"},"N/A","N/A","N/A","N/A"]
[null,null,"Lower 95%",{"$f":"IF(OR(ISBLANK(D$41),ISNA(D$41),D$41=\"N/A\"),\"N/A\",D$37-_xlfn.CONFIDENCE.NORM(0.05,D$38,COUNTA(D$41:D$1040)))","v":0.64161814685087792},{"$f":"IF(OR(ISBLANK(E$41),ISNA(E$41),E$41=\"N/A\"),\"N/A\",E$37-_xlfn.CONFIDENCE.NORM(0.05,E$38,COUNTA(E$41:E$1040)))","v":-14.250106319765061},17.916664844624286,0.99673908110458687,{"$error":"#NUM!"},null,{"$f":"IF(OR(ISBLANK(J$41),ISNA(J$41),J$41=\"N/A\"),\"N/A\",J$37-_xlfn.CONFIDENCE.NORM(0.05,J$38,COUNTA(J$41:J$1040)))","v":0.64196458797308042},-1.734099378933369,15.983990131839121,0.99673908370243347,{"$error":"#NUM!"},null,{"$f":"IF(OR(ISBLANK(P$41),ISNA(P$41),P$41=\"N/A\"),\"N/A\",P$37-_xlfn.CONFIDENCE.NORM(0.05,P$38,COUNTA(P$41:P$1040)))","v":"N/A"},"N/A","N/A","N/A","N/A"]
[null,null,"Upper 95%",{"$f":"IF(OR(ISBLANK(D$41),ISNA(D$41),D$41=\"N/A\"),\"N/A\",D$37+_xlfn.CONFIDENCE.NORM(0.05,D$38,COUNTA(D$41:D$1040)))","v":0.64318543342158385},{"$f":"IF(OR(ISBLANK(E$41),ISNA(E$41),E$41=\"N/A\"),\"N/A\",E$37+_xlfn.CONFIDENCE.NORM(0.05,E$38,COUNTA(E$41:E$1040)))","v":-14.056003415108377},17.943548624899641,0.99722019775596604,{"$error":"#NUM!"},null,{"$f":"IF(OR(ISBLANK(J$41),ISNA(J$41),J$41=\"N/A\"),\"N/A\",J$37+_xlfn.CONFIDENCE.NORM(0.05,J$38,COUNTA(J$41:J$1040)))","v":0.64355217838079604},-1.7256739584458771,15.996430932457429,0.99722020084889484,{"$error":"#NUM!"},null,{"$f":"IF(OR(ISBLANK(P$41),ISNA(P$41),P$41=\"N/A\"),\"N/A\",P$37+_xlfn.CONFIDENCE.NORM(0.05,P$38,COUNTA(P$41:P$1040)))","v":"N/A"},"N/A","N/A","N/A","N/A"]
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